Do not use during pregnancy. One of the chemicals in Oregon grape, berberine, may cross the placenta and might cause harm to the pre-born baby. It can also be transferred to the infant through breast milk. Brain damage (kernicterus) has been reported in newborn infants exposed to berberine. Infants, especially those with jaundice, should also not use oregon grape root for this same reason. Oregon grape may lower blood sugar and may cause blood sugar to become too low in people who are also taking antidiabetes medications. Please consult your doctor regarding your medication levels and oregon grape root. Oregon grape can lower blood pressure. Oregon grape might increase the risk of blood pressure becoming too low in people who already have low blood pressure. Please consult your doctor regarding your medication levels and oregon grape root. As with any herbs and medications, please consult your doctor before taking the herbs to make sure your particular medication does not have contrindications.